It appears Muller is likely to play despite coming off at halftime over the weekend against VfL Bochum with a knock, but Mane still needs time following three months out with a leg injury. Goalkeeper Manuel Neuer is out for the season with a broken leg, seeing Yann Sommer take over in net. Noussair Mazraoui has been sidelined with heart inflammation after a bout with COVID-19 and has no timeline for a return, while Lucas Hernandez faces a long spell on the sidelines after his torn ACL at the World Cup. MORE: Complete UEFA Champions League Round of 16 fixtures PSG vs Bayern Munich key stats This game is a rematch of the 2020 Champions League final in which Bayern Munich emerged victorious 1-0 thanks to a 59th minute goal by Kingsley Coman. Eight of the 15 Bayern Munich players who appeared in that match are no longer with the club, while one other (Neuer) is absent for this match. These two teams have met on 11 previous occasions, and have never drawn.

Sommer is an exceptional replacement for Neuer, while Alphonso Davies coming off the bench is a scary proposition. Meanwhile, PSG are floundering. None of the attacking three have been able to carry the load up front while the other two are injured, and that was especially true for Neymar over the weekend against Monaco. Messi could return for this game, but given the reports on his injury, it'd be surprising if he was fully effective.

The visiting side has won just three of 10 matches, not including the 2017 final played at a neutral venue. 19-year-old Jamal Musiala became the youngest player to ever make 100 appearances for Bayern Munich in December. PSG vs Bayern Munich prediction Moneyline lean: Bayern Munich (+145) Against the spread lean (handicap): Bayern Munich -0.

Bayern also face a fierce battle domestically, sitting just a point above Union Berlin and three clear of Borussia Dortmund in the Bundesliga table. They suffered through a damaging string of draws in January, but have responded with a pair of consecutive league wins. Both sides are injury stricken up front, with PSG sweating the fitness of Kylian Mbappe and Lionel Messi, while Bayern continue to be without the services of Sadio Mane.

PSG vs Bayern Munich prediction, odds, betting tips and best

It's hard to imagine anything other than a Bayern win here, and an early advantage in the two-legged matchup. PSG vs Bayern Munich: Best bet Pick: Bayern Munich to win Odds: +145 (BetMGM) No reason to overthink this one. At this point, there's no signs that PSG can overcome a German side that's just flat out better. While Bayern may be missing some key pieces, they more than have the depth to make up for it, and they have found their form again after a tough January stretch. Serge Gnabry and Musiala have rediscovered their attacking form, and Joao Cancelo's addition from Man City has been a positive one.

PSG vs Bayern Munich prediction, odds, betting tips and best bets for Champions League first legThe return of Champions League action this season couldn't possibly come at a worse time for PSG as they gear up to play German champions Bayern Munich in the first leg of their Round of 16 series. Dealing with a host of injuries that have stymied their domestic form, PSG will limp into the UEFA continental competition's knockout stage amid a miserable run of matches that has seen their Ligue 1 dominance challenged.

Marco Verratti will be an important name to keep an eye on as well, as he took a knock over the weekend and will be assessed. Renato Sanches is out, as is Nordi Mukiele. Centre-back Presnel Kimpembe returned off the bench against Monaco and he could make his full return in this game. Bayern have a number of players struggling ahead of this match. A pair of attackers are in a fitness race, with Mane and Thomas Muller doubtful.

PSG vs Bayern Munich: Times, how to watch on TV, stream

How to watch PSG v Bayern Munich in the Champions